Azaz has recently been targeted by so-called Islamic State (IS).
The latest blast comes amid a nationwide ceasefire – brokered by Russia and Turkey. It has been mainly observed, despite some violations.
No group has yet said it carried out the bombing, which according to some reports may have killed as many as 60 people and injured many more.
The activist group Syrian Observatory for Human Rights said six rebels were among the dead, with the rest believed to be civilians.
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